Ontology highlight
ABSTRACT:
SUBMITTER: El Messaoudi-Aubert S
PROVIDER: S-EPMC2929459 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
El Messaoudi-Aubert Selma S Nicholls James J Maertens Goedele N GN Brookes Sharon S Bernstein Emily E Peters Gordon G
Nature structural & molecular biology 20100613 7
Several lines of evidence point to a role for noncoding RNA in transcriptional repression by Polycomb group (PcG) proteins, but the precise mechanism remains unclear. Here we show that human MOV10, a putative RNA helicase previously implicated in post-transcriptional gene silencing, co-purifies and interacts with components of Polycomb-repressive complex 1 (PRC1) from human cells. Endogenous human MOV10 is mostly nuclear, and a proportion associates with chromatin in an RNA-dependent manner. Sma ...[more]