Ontology highlight
ABSTRACT:
SUBMITTER: Neelakanta G
PROVIDER: S-EPMC2929727 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Neelakanta Girish G Sultana Hameeda H Fish Durland D Anderson John F JF Fikrig Erol E
The Journal of clinical investigation 20100825 9
In the United States, Ixodes scapularis ticks overwinter in the Northeast and Upper Midwest and transmit the agent of human granulocytic anaplasmosis, Anaplasma phagocytophilum, among other pathogens. We now show that the presence of A. phagocytophilum in I. scapularis ticks increases their ability to survive in the cold. We identified an I. scapularis antifreeze glycoprotein, designated IAFGP, and demonstrated via RNAi knockdown studies the importance of IAFGP for the survival of I. scapularis ...[more]