Ontology highlight
ABSTRACT:
SUBMITTER: Bachschmid MM
PROVIDER: S-EPMC2930025 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Bachschmid Markus M MM Xu Shanqin S Maitland-Toolan Karlene A KA Ho Ye-Shih YS Cohen Richard A RA Matsui Reiko R
Free radical biology & medicine 20100716 7
Glutaredoxin-1 (Glrx) is a thioltransferase that regulates protein S-glutathiolation. To elucidate the role of endogenous Glrx in cardiovascular disease, Glrx knockout (KO) mice were infused with angiotensin II (Ang II) for 6days. After Ang II infusion, body weight and blood pressure were similar between WT and Glrx KO mice. However, compared to WT mice, Glrx KO mice demonstrated (1) less cardiac and aortic medial hypertrophy, (2) less oxidant generation in aorta as assessed by dihydroethidium s ...[more]