Ontology highlight
ABSTRACT:
SUBMITTER: Proshkin S
PROVIDER: S-EPMC2930199 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Proshkin Sergey S Rahmouni A Rachid AR Mironov Alexander A Nudler Evgeny E
Science (New York, N.Y.) 20100401 5977
During transcription of protein-coding genes, bacterial RNA polymerase (RNAP) is closely followed by a ribosome that translates the newly synthesized transcript. Our in vivo measurements show that the overall elongation rate of transcription is tightly controlled by the rate of translation. Acceleration and deceleration of a ribosome result in corresponding changes in the speed of RNAP. Moreover, we found an inverse correlation between the number of rare codons in a gene, which delay ribosome pr ...[more]