Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC2930457 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Chen Xing X Xie Can C Nishida Noritaka N Li Zongli Z Walz Thomas T Springer Timothy A TA
Proceedings of the National Academy of Sciences of the United States of America 20100802 33
Negative stain electron microscopy (EM) and adhesion assays show that alpha(X)beta(2) integrin activation requires headpiece opening as well as extension. An extension-inducing Fab to the beta(2) leg, in combination with representative activating and inhibitory Fabs, were examined for effect on the equilibrium between the open and closed headpiece conformations. The two activating Fabs stabilized the open headpiece conformation. Conversely, two different inhibitory Fabs stabilized the closed hea ...[more]