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Successive-signal biasing for a learned sound sequence.

ABSTRACT: Adult rats were trained to detect the occurrence of a two-element sound sequence in a background of nine other nontarget sound pairs. Training resulted in a modest, enduring, static expansion of the cortical areas of representation of both target stimulus sounds. More importantly, once the initial stimulus A in the target A-B sequence was presented, the cortical "map" changed dynamically, specifically to exaggerate further the representation of the "anticipated" stimulus B. If B occurred, it was represented over a larger cortical area by more strongly excited, more coordinated, and more selectively responding neurons. This biasing peaked at the expected time of B onset with respect to A onset. No dynamic biasing of responses was recorded for any sound presented in a nontarget pair. Responses to nontarget frequencies flanking the representation of B were reduced in area and in response strength only after the presentation of A at the expected time of B onset. This study shows that cortical areas are not representationally static but, to the contrary, can be biased moment by moment in time as a function of behavioral context.

SUBMITTER: Zhou X

PROVIDER: S-EPMC2930458 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Successive-signal biasing for a learned sound sequence.

Zhou Xiaoming X de Villers-Sidani Etienne E Panizzutti Rogerio R Merzenich Michael M MM

Proceedings of the National Academy of Sciences of the United States of America 20100802 33

Adult rats were trained to detect the occurrence of a two-element sound sequence in a background of nine other nontarget sound pairs. Training resulted in a modest, enduring, static expansion of the cortical areas of representation of both target stimulus sounds. More importantly, once the initial stimulus A in the target A-B sequence was presented, the cortical "map" changed dynamically, specifically to exaggerate further the representation of the "anticipated" stimulus B. If B occurred, it was ...[more]

PMID: 20679210

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Dataset Information

Successive-signal biasing for a learned sound sequence.

Publications

Successive-signal biasing for a learned sound sequence.

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