Ontology highlight
ABSTRACT:
SUBMITTER: Chen VP
PROVIDER: S-EPMC2930726 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Chen Vicky P VP Xie Heidi Q HQ Chan Wallace K B WKB Leung K Wing KW Chan Gallant K L GKL Choi Roy C Y RCY Bon Suzanne S Massoulié Jean J Tsim Karl W K KWK
The Journal of biological chemistry 20100621 35
Acetylcholinesterase (AChE) is anchored onto cell membranes by the transmembrane protein PRiMA (proline-rich membrane anchor) as a tetrameric globular form that is prominently expressed in vertebrate brain. In parallel, the PRiMA-linked tetrameric butyrylcholinesterase (BChE) is also found in the brain. A single type of AChE-BChE hybrid tetramer was formed in cell cultures by co-transfection of cDNAs encoding AChE(T) and BChE(T) with proline-rich attachment domain-containing proteins, PRiMA I, P ...[more]