Ontology highlight
ABSTRACT:
SUBMITTER: Fieni F
PROVIDER: S-EPMC2930739 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Fieni Francesca F Parkar Anjum A Misgeld Thomas T Kerschensteiner Martin M Lichtman Jeff W JW Pasinelli Piera P Trotti Davide D
The Journal of biological chemistry 20100615 35
Potassium fluxes integrate mitochondria into cellular activities, controlling their volume homeostasis and structural integrity in many pathophysiological mechanisms. The outer mitochondrial membrane (OMM) is thought to play a passive role in this process because K(+) is believed to equilibrate freely between the cytosol and mitochondrial intermembrane space. By patch clamping mitochondria isolated from the central nervous systems of adult mitoCFP transgenic mice, we discovered the existence of ...[more]