Ontology highlight
ABSTRACT:
SUBMITTER: Cormont M
PROVIDER: S-EPMC29309 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Cormont M M Mari M M Galmiche A A Hofman P P Le Marchand-Brustel Y Y
Proceedings of the National Academy of Sciences of the United States of America 20010130 4
The small GTPase Rab4 is implicated in endocytosis in all cell types, but also plays a specific role in some regulated processes. To better understand the role of Rab4 in regulation of vesicular trafficking, we searched for an effector(s) that specifically recognizes its GTP-bound form. We cloned a ubiquitous 69-kDa protein, Rabip4, that behaves as a Rab4 effector in the yeast two-hybrid system and in the mammalian cell. Rabip4 contains two coiled-coil domains and a FYVE-finger domain. When expr ...[more]