Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC2931336 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Zhang Zhiwu Z Ersoz Elhan E Lai Chao-Qiang CQ Todhunter Rory J RJ Tiwari Hemant K HK Gore Michael A MA Bradbury Peter J PJ Yu Jianming J Arnett Donna K DK Ordovas Jose M JM Buckler Edward S ES
Nature genetics 20100307 4
Mixed linear model (MLM) methods have proven useful in controlling for population structure and relatedness within genome-wide association studies. However, MLM-based methods can be computationally challenging for large datasets. We report a compression approach, called 'compressed MLM', that decreases the effective sample size of such datasets by clustering individuals into groups. We also present a complementary approach, 'population parameters previously determined' (P3D), that eliminates the ...[more]