Ontology highlight
ABSTRACT:
SUBMITTER: Portis AM
PROVIDER: S-EPMC2931363 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Microscopy research and technique 20100901 9
Clinical applications of genetic therapies, including delivery of short, interfering RNAs (siRNAs) for RNA interference (RNAi), are limited due to the difficulty of delivering nucleic acids to specific cells of interest while at the same time minimizing toxicity and immunogenicity. The use of cationic polymers to deliver nucleic acid therapeutics has the potential to address these complex issues but is currently limited by low-delivery efficiencies. Although cell culture studies have shown that ...[more]