Unknown

Dataset Information

0

Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.


ABSTRACT: Enhanced mesenchymal expression of FGF10 led to the formation of multifocal PIN or prostate cancer. Inhibition of epithelial FGFR1 signaling using DN FGFR1 led to reversal of the cancer phenotype. A subset of the FGF10-induced carcinoma was serially transplantable. Paracrine FGF10 led to an increase in epithelial androgen receptor and synergized with cell-autonomous activated AKT. Our observations indicate that stromal FGF10 expression may facilitate the multifocal histology observed in prostate adenocarcinoma and suggest the FGF10/FGFR1 axis as a potential therapeutic target in treating hormone-sensitive or refractory prostate cancer. We also show that transient exposure to a paracrine growth factor may be sufficient for the initiation of oncogenic transformation.

SUBMITTER: Memarzadeh S 

PROVIDER: S-EPMC2931420 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.

Memarzadeh Sanaz S   Xin Li L   Mulholland David J DJ   Mansukhani Alka A   Wu Hong H   Teitell Michael A MA   Witte Owen N ON  

Cancer cell 20071201 6


Enhanced mesenchymal expression of FGF10 led to the formation of multifocal PIN or prostate cancer. Inhibition of epithelial FGFR1 signaling using DN FGFR1 led to reversal of the cancer phenotype. A subset of the FGF10-induced carcinoma was serially transplantable. Paracrine FGF10 led to an increase in epithelial androgen receptor and synergized with cell-autonomous activated AKT. Our observations indicate that stromal FGF10 expression may facilitate the multifocal histology observed in prostate  ...[more]

Similar Datasets

| S-EPMC3022749 | biostudies-literature
| S-EPMC8866211 | biostudies-literature
| S-EPMC3236336 | biostudies-literature
| S-EPMC3894334 | biostudies-literature
| S-EPMC3000385 | biostudies-literature
| S-EPMC4874596 | biostudies-literature
| S-EPMC5026614 | biostudies-literature
| S-EPMC5581025 | biostudies-literature
| S-EPMC1937526 | biostudies-literature
| S-EPMC3725282 | biostudies-literature