Ontology highlight
ABSTRACT:
SUBMITTER: McCully ME
PROVIDER: S-EPMC2931720 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
McCully Michelle E ME Beck David A C DA Fersht Alan R AR Daggett Valerie V
Biophysical journal 20100901 5
The ultrafast folding pathway of the engrailed homeodomain has been exceptionally well characterized by experiment and simulation. Helices II and III of the three-helix bundle protein form the native helix-turn-helix motif as an on-pathway intermediate within a few microseconds. The slow step is then the proper docking of the helices in approximately 15 mus. However, there is still the unexplained puzzle of why helix docking is relatively slow, which is part of the more general question as to wh ...[more]