Ontology highlight
ABSTRACT:
SUBMITTER: Suh BC
PROVIDER: S-EPMC2931829 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Suh Byung-Chang BC Leal Karina K Hille Bertil B
Neuron 20100701 2
Modulation of voltage-gated Ca(2+) channels controls activities of excitable cells. We show that high-voltage activated Ca(2+) channels are regulated by membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) with different sensitivities. Plasma membrane PIP(2) depletion by rapamycin-induced translocation of an inositol lipid 5-phosphatase or by a voltage-sensitive 5-phosphatase (VSP) suppresses Ca(V)1.2 and Ca(V)1.3 channel currents by approximately 35% and Ca(V)2.1 and Ca(V)2.2 currents by 29% ...[more]