Ontology highlight
ABSTRACT:
SUBMITTER: Conery AR
PROVIDER: S-EPMC2932617 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Conery Andrew R AR Harlow Ed E
Proceedings of the National Academy of Sciences of the United States of America 20100816 35
Chromosomal instability and the subsequent genetic mutations are considered to be critical factors in the development of the majority of solid tumors, but the mechanisms by which a stable diploid cell loses the ability to maintain genomic integrity are not well characterized. We have approached this critical issue through the use of high-throughput screens in untransformed diploid epithelial cells. In a screen of a cDNA library, we identified 13 kinases whose overexpression leads to increased pl ...[more]