Regulation of notch1 signaling by nrf2: implications for tissue regeneration.
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ABSTRACT:
SUBMITTER: Wakabayashi N
PROVIDER: S-EPMC2932745 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Regulation of notch1 signaling by nrf2: implications for tissue regeneration.
Wakabayashi Nobunao N Shin Soona S Slocum Stephen L SL Agoston Elin S ES Wakabayashi Junko J Kwak Mi-Kyoung MK Misra Vikas V Biswal Shyam S Yamamoto Masayuki M Kensler Thomas W TW
Science signaling 20100713 130
The Keap1-Nrf2-ARE signaling pathway elicits an adaptive response for cell survival after endogenous and exogenous stresses, such as inflammation and carcinogens, respectively. Keap1 inhibits the transcriptional activation activity of Nrf2 (p45 nuclear factor erythroid-derived 2-related factor 2) in unstressed cells by facilitating its degradation. Through transcriptional analyses in Keap1- or Nrf2-disrupted mice, we identified interactions between the Keap1-Nrf2-ARE and the Notch1 signaling pat ...[more]
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