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Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.


ABSTRACT: BACKGROUND:Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway. METHODS:Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284). RESULTS:In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed. CONCLUSION:Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.

SUBMITTER: Sezgin E 

PROVIDER: S-EPMC2932829 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS.

Sezgin Efe E   Jabs Douglas A DA   Hendrickson Sher L SL   Van Natta Mark M   Zdanov Alexander A   Lewis Richard Alan RA   Smith Michael W MW   Troyer Jennifer L JL   O'Brien Stephen J SJ  

The Journal of infectious diseases 20100801 4


<h4>Background</h4>Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway.<h4>Methods</h4>Effects of IL-10R1, IL-10 and previously described AIDS rest  ...[more]

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