Ontology highlight
ABSTRACT:
SUBMITTER: Glykys J
PROVIDER: S-EPMC2932871 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Glykys Joseph J Dzhala Volodymyr I VI Kuchibhotla Kishore V KV Feng Guoping G Kuner Thomas T Augustine George G Bacskai Brian J BJ Staley Kevin J KJ
Neuron 20090901 5
Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest. Uncoupling increases after treatment with Phenobarbital, which enhances the GABA(A) receptor (GABA(A)R) conductance. The effects of GABA(A)R activation depend on the intracellular Cl(-) concentration ([Cl(-)](i)) that is determined by the inward Cl(-) transporter NKCC1 and the outward Cl(-) transporter KCC2. Differential maturation of Cl(-) transport observed in cortical ver ...[more]