Ontology highlight
ABSTRACT:
SUBMITTER: Morris KA
PROVIDER: S-EPMC2933739 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Organic letters 20100901 17
A double diastereoselective variant of the nucleophile-catalyzed aldol lactonization (NCAL) process is described. This strategy delivers beta-lactone-fused carbocycles with good to excellent diastereoselectivities using cinchona alkaloid catalysts with enantioenriched aldehyde acids, which gave low diastereoselectivity based on substrate control alone. beta-Lactone-fused tetrahydrofurans are also prepared for the first time via the NCAL process; however, diastereoselectivity was only modestly im ...[more]