Ontology highlight
ABSTRACT:
SUBMITTER: Ellenberger T
PROVIDER: S-EPMC2933818 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Annual review of biochemistry 20080101
DNA ligases are required for DNA replication, repair, and recombination. In eukaryotes, there are three families of ATP-dependent DNA ligases. Members of the DNA ligase I and IV families are found in all eukaryotes, whereas DNA ligase III family members are restricted to vertebrates. These enzymes share a common catalytic region comprising a DNA-binding domain, a nucleotidyltransferase (NTase) domain, and an oligonucleotide/oligosaccharide binding (OB)-fold domain. The catalytic region encircles ...[more]