Ontology highlight
ABSTRACT:
SUBMITTER: Yee NS
PROVIDER: S-EPMC2933954 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Yee Nelson S NS Zhou Weiqiang W Lee Minsun M
Cancer letters 20100601 1
The roles of transient receptor potential (TRP) cation channels in pancreatic tumorigenesis are essentially unknown. Here, we focus on the TRP melastatin-subfamily (TRPM) members. Expression of the thermally regulated transmembrane Ca(2+)-permeable channel TRPM8 is consistently up-regulated in human pancreatic adenocarcinoma cell lines and tissues. TRPM8-deficient pancreatic cancer cells have reduced ability of proliferation and cell cycle progression with elevated levels of cyclin-dependent kin ...[more]