Ontology highlight
ABSTRACT:
SUBMITTER: Sun P
PROVIDER: S-EPMC2934621 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Sun Peng P Nallar Shreeram C SC Raha Abhijit A Kalakonda Sudhakar S Velalar Chidambaram N CN Reddy Sekhar P SP Kalvakolanu Dhananjaya V DV
The Journal of biological chemistry 20100603 36
GRIM-19 (Gene associated with Retinoid-IFN-induced Mortality-19) was originally isolated as a growth suppressor in a genome-wide knockdown screen with antisense libraries. Like classical tumor suppressors, mutations, and/or loss of GRIM-19 expression occur in primary human tumors; and it is inactivated by viral gene products. Our search for potential GRIM-19-binding proteins, using mass spectrometry, that permit its antitumor actions led to the inhibitor of cyclin-dependent kinase 4, CDKN2A. The ...[more]