Ontology highlight
ABSTRACT:
SUBMITTER: Ravasio A
PROVIDER: S-EPMC2934682 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Ravasio Andrea A Olmeda Bárbara B Bertocchi Cristina C Haller Thomas T Pérez-Gil Jesús J
The Journal of biological chemistry 20100617 36
Pulmonary surfactant is essential for lung function. It is assembled, stored and secreted as particulate entities (lamellar body-like particles; LBPs). LBPs disintegrate when they contact an air-liquid interface, leading to an instantaneous spreading of material and a decline in surface tension. Here, we demonstrate that the film formed by the adsorbed material spontaneously segregate into distinct ordered and disordered lipid phase regions under unprecedented near-physiological conditions and, ...[more]