Ontology highlight
ABSTRACT:
SUBMITTER: Beecham GW
PROVIDER: S-EPMC2934779 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Beecham Gary W GW Martin Eden R ER Gilbert John R JR Haines Jonathan L JL Pericak-Vance Margaret A MA
Annals of human genetics 20100501 3
With the advent of publicly available genome-wide genotyping data, the use of genotype imputation methods is becoming increasingly common. These methods are of particular use in joint analyses, where data from different genotyping platforms are imputed to a reference set and combined in a single analysis. We show here that such an analysis can miss strong genetic association signals, such as that of the apolipoprotein-e gene in late-onset Alzheimer disease. This can occur in regions of weak to m ...[more]