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N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis.


ABSTRACT: A "2-hit" model for nonalcoholic steatohepatitis (NASH) has been proposed in which steatosis constitutes the "first hit" and sensitizes the liver to potential "second hits" resulting in NASH. Oxidative stress is considered a candidate for the second hit. N-acetylcysteine (NAC), an antioxidant, has been suggested as a dietary therapy for NASH. We examined the effects of NAC in a rat total enteral nutrition (TEN) model where NASH develops as the result of overfeeding dietary polyunsaturated fat. Male Sprague-Dawley rats consumed pelleted AIN-93G diets ad libitum or were overfed a 9200 kJ.kg(-0.75).d(-1) liquid diet containing 70% corn oil with or without 2 g.kg(-1).d(-1) NAC i.g. for 65 d. Hepatic steatosis was not influenced by dietary supplementation with NAC; however, the liver pathology score was lower (P

SUBMITTER: Baumgardner JN 

PROVIDER: S-EPMC2935161 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis.

Baumgardner January N JN   Shankar Kartik K   Hennings Leah L   Albano Emanuele E   Badger Thomas M TM   Ronis Martin J J MJ  

The Journal of nutrition 20081001 10


A "2-hit" model for nonalcoholic steatohepatitis (NASH) has been proposed in which steatosis constitutes the "first hit" and sensitizes the liver to potential "second hits" resulting in NASH. Oxidative stress is considered a candidate for the second hit. N-acetylcysteine (NAC), an antioxidant, has been suggested as a dietary therapy for NASH. We examined the effects of NAC in a rat total enteral nutrition (TEN) model where NASH develops as the result of overfeeding dietary polyunsaturated fat. M  ...[more]

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