Ontology highlight
ABSTRACT:
SUBMITTER: Rudolph MJ
PROVIDER: S-EPMC2935214 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Rudolph Michael J MJ Amodeo Gabriele A GA Tong Liang L
Acta crystallographica. Section F, Structural biology and crystallization communications 20100821 Pt 9
AMP-activated protein kinase (AMPK) is a master metabolic regulator for controlling cellular energy homeostasis. Its homolog in yeast, SNF1, is activated in response to glucose depletion and other stresses. The catalytic (alpha) subunit of AMPK/SNF1 in yeast (Snf1) contains a protein Ser/Thr kinase domain (KD), an auto-inhibitory domain (AID) and a region that mediates interactions with the two regulatory (beta and gamma) subunits. Here, the crystal structure of residues 41-440 of Snf1, which in ...[more]