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Structure of a stacked anthraquinone-DNA complex.


ABSTRACT: The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G.G and A.UBr reverse Watson-Crick base pairs.

SUBMITTER: De Luchi D 

PROVIDER: S-EPMC2935217 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Structure of a stacked anthraquinone-DNA complex.

De Luchi Daniela D   Usón Isabel I   Wright Glenford G   Gouyette Catherine C   Subirana Juan A JA  

Acta crystallographica. Section F, Structural biology and crystallization communications 20100821 Pt 9


The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G.G and A.UBr reverse Watson-Crick base pairs. ...[more]

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