Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC2936629 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Yang Sichun S Blachowicz Lydia L Makowski Lee L Roux Benoît B
Proceedings of the National Academy of Sciences of the United States of America 20100823 36
An approach combining small-angle X-ray solution scattering (SAXS) data with coarse-grained (CG) simulations is developed to characterize the assembly states of Hck, a member of the Src-family kinases, under various conditions in solution. First, a basis set comprising a small number of assembly states is generated from extensive CG simulations. Second, a theoretical SAXS profile for each state in the basis set is computed by using the Fast-SAXS method. Finally, the relative population of the di ...[more]