Ontology highlight
ABSTRACT:
SUBMITTER: Aung LL
PROVIDER: S-EPMC2937086 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Aung Latt Latt LL Fitzgerald-Bocarsly Patricia P Dhib-Jalbut Suhayl S Balashov Konstantin K
Journal of neuroimmunology 20100901 1-2
Plasmacytoid dendritic cells (pDCs) are present in peripheral blood, leptomeninges and demyelinating lesions in patients with multiple sclerosis (MS). The ability of pDCs to produce chemokines and express the chemokine receptor CCR7 in MS is not known. We studied pDCs in MS patients and healthy subjects. The ability of pDCs to up-regulate CCR7 was significantly increased in untreated MS patients as compared to healthy subjects. IFN-beta treatment significantly inhibited TLR9 agonist-specific sec ...[more]