Pharmacogenetics of drug hypersensitivity.
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ABSTRACT:
SUBMITTER: Phillips EJ
PROVIDER: S-EPMC2937181 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Pharmacogenetics of drug hypersensitivity.
Phillips Elizabeth J EJ Mallal Simon A SA
Pharmacogenomics 20100701 7
Drug hypersensitivity reactions and severe cutaneous adverse drug reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, are examples of serious adverse drug reactions mediated through a combination of metabolic and immunological mechanisms that could traditionally not have been predicted based on the pharmacological characteristics of the drug alone. The discovery of new associations between these syndromes and specific HLA has created the promise that risk for these reacti ...[more]
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