Ontology highlight
ABSTRACT:
SUBMITTER: Fruebis J
PROVIDER: S-EPMC29372 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Fruebis J J Tsao T S TS Javorschi S S Ebbets-Reed D D Erickson M R MR Yen F T FT Bihain B E BE Lodish H F HF
Proceedings of the National Academy of Sciences of the United States of America 20010206 4
Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated adipocytes; its mRNA is decreased in obese humans and mice. Here we describe novel pharmacological properties of the protease-generated globular head domain of Acrp30 (gAcrp30). Acute treatment of mice with gAcrp30 significantly decreased the elevated levels of plasma free fatty acids caused either by administration of a high fat test meal or by i.v. injectio ...[more]