Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon.
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ABSTRACT:
SUBMITTER: Chubiz LM
PROVIDER: S-EPMC2937402 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon.
Chubiz Lon M LM Rao Christopher V CV
Journal of bacteriology 20100716 18
MarR is a key regulator of the marRAB operon involved in antibiotic resistance and solvent stress tolerance in Escherichia coli. We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan biosynthesis, respectively, can activate marRAB transcription. We also found that a third intermediate involved in ubiquinone biosynthesis, 4-hydroxybenzoate, activates marRAB transcription in the absence of TolC. Of the three, however, only 2,3-dih ...[more]
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