Role of catabolite control protein A in the regulation of intermedilysin production by Streptococcus intermedius.

ABSTRACT: Streptococcus intermedius is an opportunistic pathogen of humans that causes purulent infections, including brain and liver abscesses. This pathogen secretes a human-specific cytolysin, intermedilysin, which has been recognized as a major virulence factor. However, most of the expressional control mechanisms of ily are still unknown. To determine these mechanisms, we analyzed the nucleotide sequence of the ily promoter region. We found a highly homologous region to the catabolite-repressible element (cre) in the ily promoter region and observed a considerable decrease in the amount of secreted intermedilysin when cells were grown in a culture medium containing high concentrations of glucose/utilizable carbohydrates. Disruption of the ccpA gene, which encodes catabolite control protein A, d

SUBMITTER: Tomoyasu T 

PROVIDER: S-EPMC2937470 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature