Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory.
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ABSTRACT:
SUBMITTER: Keller PM
PROVIDER: S-EPMC2937732 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory.
Keller Peter M PM Rampini Silvana K SK Büchler Andrea C AC Eich Gerhard G Wanner Roger M RM Speck Roberto F RF Böttger Erik C EC Bloemberg Guido V GV
Journal of clinical microbiology 20100714 9
Clinical isolates that are difficult to identify by conventional means form a valuable source of novel human pathogens. We report on a 5-year study based on systematic 16S rRNA gene sequence analysis. We found 60 previously unknown 16S rRNA sequences corresponding to potentially novel bacterial taxa. For 30 of 60 isolates, clinical relevance was evaluated; 18 of the 30 isolates analyzed were considered to be associated with human disease. ...[more]
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