Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2937794 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Liu Jinyan J Keele Brandon F BF Li Hui H Keating Sheila S Norris Philip J PJ Carville Angela A Mansfield Keith G KG Tomaras Georgia D GD Haynes Barton F BF Kolodkin-Gal Dror D Letvin Norman L NL Hahn Beatrice H BH Shaw George M GM Barouch Dan H DH
Journal of virology 20100804 19
Defining the earliest virologic events following human immunodeficiency virus type 1 (HIV-1) transmission may be critical for the design of vaccine strategies aimed at blocking acquisition of HIV-1 infection. In particular, the length of the eclipse phase and the number of transmitted virus variants may define the window in which a prophylactic vaccine must act. Here we show that the dose of the virus inoculum affects these key virologic parameters following intrarectal simian immunodeficiency v ...[more]