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Integrative structure modeling of macromolecular assemblies from proteomics data.

ABSTRACT: Proteomics techniques have been used to generate comprehensive lists of protein interactions in a number of species. However, relatively little is known about how these interactions result in functional multiprotein complexes. This gap can be bridged by combining data from proteomics experiments with data from established structure determination techniques. Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures.

SUBMITTER: Lasker K

PROVIDER: S-EPMC2938050 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Integrative structure modeling of macromolecular assemblies from proteomics data.

Lasker Keren K Phillips Jeremy L JL Russel Daniel D Velázquez-Muriel Javier J Schneidman-Duhovny Dina D Tjioe Elina E Webb Ben B Schlessinger Avner A Sali Andrej A

Molecular & cellular proteomics : MCP 20100527 8

Proteomics techniques have been used to generate comprehensive lists of protein interactions in a number of species. However, relatively little is known about how these interactions result in functional multiprotein complexes. This gap can be bridged by combining data from proteomics experiments with data from established structure determination techniques. Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of acc ...[more]

PMID: 20507923

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