Ontology highlight
ABSTRACT:
SUBMITTER: Park JJ
PROVIDER: S-EPMC2938239 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Park Jang-June JJ Omiya Ryusuke R Matsumura Yumiko Y Sakoda Yukimi Y Kuramasu Atsuo A Augustine Mathew M MM Yao Sheng S Tsushima Fumihiko F Narazaki Hidehiko H Anand Sudarshan S Liu Yingjia Y Strome Scott E SE Chen Lieping L Tamada Koji K
Blood 20100514 8
T-cell tolerance is the central program that prevents harmful immune responses against self-antigens, in which inhibitory PD-1 signal given by B7-H1 interaction plays an important role. Recent studies demonstrated that B7-H1 binds CD80 besides PD-1, and B7-H1/CD80 interaction also delivers inhibitory signals in T cells. However, a role of B7-H1/CD80 signals in regulation of T-cell tolerance has yet to be explored. We report here that attenuation of B7-H1/CD80 signals by treatment with anti-B7-H1 ...[more]