Ontology highlight
ABSTRACT:
SUBMITTER: Ochi T
PROVIDER: S-EPMC2938450 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ochi Takashi T Sibanda Bancinyane Lynn BL Wu Qian Q Chirgadze Dimitri Y DY Bolanos-Garcia Victor M VM Blundell Tom L TL
Journal of nucleic acids 20100825
Nonhomologous end joining (NHEJ) plays a major role in double-strand break DNA repair, which involves a series of steps mediated by multiprotein complexes. A ring-shaped Ku70/Ku80 heterodimer forms first at broken DNA ends, DNA-dependent protein kinase catalytic subunit (DNA-PKcs) binds to mediate synapsis and nucleases process DNA overhangs. DNA ligase IV (LigIV) is recruited as a complex with XRCC4 for ligation, with XLF/Cernunnos, playing a role in enhancing activity of LigIV. We describe how ...[more]