Clinical translation of genetic predictors for type 2 diabetes.

ABSTRACT:

Purpose of review

To highlight recent type 2 diabetes (T2D)-associated genetic discoveries and their potential for clinical application.

Recent findings

The advent of genome-wide association screening has uncovered many loci newly associated with T2D. This review describes the techniques applied to discover novel T2D genes and compares their relative strengths, biases, and findings to date. The results of large-scale genome-wide association studies carried out since 2007 are summarized, and limitations of interpreting this preliminary data are offered. Recent studies exploring the clinical potential of these discoveries are reviewed, focusing on insights into T2D pathogenesis, risk prediction of future diabetes, and utility in guiding pharmacotherapy. The new T2D-associated

SUBMITTER: Majithia AR 

PROVIDER: S-EPMC2938779 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature