Ontology highlight
ABSTRACT:
SUBMITTER: Cheung VG
PROVIDER: S-EPMC2939022 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Cheung Vivian G VG Nayak Renuka R RR Wang Isabel Xiaorong IX Elwyn Susannah S Cousins Sarah M SM Morley Michael M Spielman Richard S RS
PLoS biology 20100914 9
Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in genetic studies where the entire genome can be scanned for regulators without prior knowledge of the regulatory mechanisms, thus enabling the identification of unknown regulatory relationships. Here, we carried out such genetic analyses with a large sample size and identified cis- and trans-acting polymorphic regulators for about 1,000 human ...[more]