Ontology highlight
ABSTRACT:
SUBMITTER: Sievers C
PROVIDER: S-EPMC2939069 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Sievers Claudia C Billig Gwendolyn G Gottschalk Kathleen K Rudel Thomas T
PloS one 20100914 9
Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane. Although it was originally identified by its ability to inhibit G1/S progression in human fibroblasts, its role as tumor suppressor is debated. To determine the function of prohibitins in maintaining cell homeostasis, we generated cancer cell lines expressing prohibitin-directed shRNAs. We show that prohibitin proteins are necessary for the ...[more]