Ontology highlight
ABSTRACT:
SUBMITTER: Renfranz PJ
PROVIDER: S-EPMC2939194 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Renfranz Patricia J PJ Blankman Elizabeth E Beckerle Mary C MC
Anatomical record (Hoboken, N.J. : 2007) 20100901 9
The zyxin family of proteins function as cytoskeletal regulators in adhesion, actin assembly, and cell motility. Though fibroblasts derived from zyxin-null mice show striking defects in motility and response to mechanical stimuli, the mice are viable and fertile. In Drosophila melanogaster, the family is represented by a single homologue, Zyx102. To study the role of zyxin during development, we generated a zyx102 RNA-interference transgenic line that allows for the conditional knockdown of Zyx1 ...[more]