Ontology highlight
ABSTRACT:
SUBMITTER: Karalewitz AP
PROVIDER: S-EPMC2939319 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Karalewitz Andrew P-A AP Kroken Abby R AR Fu Zhuji Z Baldwin Michael R MR Kim Jung-Ja P JJ Barbieri Joseph T JT
Biochemistry 20100901 37
The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A-G) based on a lack of cross antiserum neutralization. BoNTs utilize gangliosides as components of the host receptors for binding and entry into neurons. Members of BoNT/C and BoNT/D serotypes include mosaic toxins that are organized in D/C and C/D toxins. One D/C mosaic toxin, BoNT/D-South Africa (BoNT/D-SA), was not fully neutralized by immunization with BoNT serotype C or D, w ...[more]