Ontology highlight
ABSTRACT:
SUBMITTER: Dowell NL
PROVIDER: S-EPMC2939365 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Dowell Noah L NL Sperling Adam S AS Mason Michael J MJ Johnson Reid C RC
Genes & development 20100901 18
The Saccharomyces cerevisiae protein Nhp6A is a model for the abundant and multifunctional high-mobility group B (HMGB) family of chromatin-associated proteins. Nhp6A binds DNA in vitro without sequence specificity and bends DNA sharply, but its role in chromosome biology is poorly understood. We show by whole-genome chromatin immunoprecipitation (ChIP) and high-resolution whole-genome tiling arrays (ChIP-chip) that Nhp6A is localized to specific regions of chromosomes that include ∼23% of RNA p ...[more]