Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.
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ABSTRACT:
SUBMITTER: Yang Q
PROVIDER: S-EPMC2939729 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.
Yang Qingkai Q Deng Xianming X Lu Bingwen B Cameron Michael M Fearns Colleen C Patricelli Matthew P MP Yates John R JR Gray Nathanael S NS Lee Jiing-Dwan JD
Cancer cell 20100901 3
BMK1 is activated by mitogens and oncogenic signals and, thus, is strongly implicated in tumorigenesis. We found that BMK1 interacted with promyelocytic leukemia protein (PML), and inhibited its tumor-suppressor function through phosphorylation. Furthermore, activated BMK1 notably inhibited PML-dependent activation of p21. To further investigate the BMK-mediated inhibition of the tumor suppressor activity of PML in tumor cells, we developed a small-molecule inhibitor of the kinase activity of BM ...[more]
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