Ontology highlight
ABSTRACT:
SUBMITTER: Comin-Anduix B
PROVIDER: S-EPMC2939876 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Comin-Anduix Begoña B Sazegar Hooman H Chodon Thinle T Matsunaga Douglas D Jalil Jason J von Euw Erika E Escuin-Ordinas Helena H Balderas Robert R Chmielowski Bartosz B Gomez-Navarro Jesus J Koya Richard C RC Ribas Antoni A
PloS one 20100915 9
<h4>Background</h4>The effects on cell signalling networks upon blockade of cytotoxic T lymphocyte-associated antigen-4 (CTLA4) using the monoclonal antibody tremelimumab were studied in peripheral blood mononuclear cell (PBMC) samples from patients with metastatic melanoma.<h4>Methodology/principal</h4>Findings Intracellular flow cytometry was used to detect phosphorylated (p) signaling molecules downstream of the T cell receptor (TCR) and cytokine receptors. PBMC from tremelimumab-treated pati ...[more]