Ontology highlight
ABSTRACT:
SUBMITTER: Hyter S
PROVIDER: S-EPMC2939934 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Hyter Stephen S Bajaj Gaurav G Liang Xiaobo X Barbacid Mariano M Ganguli-Indra Gitali G Indra Arup Kumar AK
Pigment cell & melanoma research 20100709 5
Keratinocytes contribute to melanocyte transformation by affecting their microenvironment, in part through the secretion of paracrine factors. Here we report a loss of expression of nuclear receptor RXRα in epidermal keratinocytes during human melanoma progression. In the absence of keratinocytic RXRα, in combination with mutant Cdk4, cutaneous melanoma was generated that metastasized to lymph nodes in a bigenic mouse model. Expression of several keratinocyte-derived mitogenic growth factors (Et ...[more]