Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC2940119 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Zhao Yongfang Y Terry Daniel D Shi Lei L Weinstein Harel H Blanchard Scott C SC Javitch Jonathan A JA
Nature 20100501 7295
Neurotransmitter:Na(+) symporters (NSS) remove neurotransmitters from the synapse in a reuptake process that is driven by the Na(+) gradient. Drugs that interfere with this reuptake mechanism, such as cocaine and antidepressants, profoundly influence behaviour and mood. To probe the nature of the conformational changes that are associated with substrate binding and transport, we have developed a single-molecule fluorescence imaging assay and combined it with functional and computational studies ...[more]