Ontology highlight
ABSTRACT:
SUBMITTER: Sloan EK
PROVIDER: S-EPMC2940980 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Sloan Erica K EK Priceman Saul J SJ Cox Benjamin F BF Yu Stephanie S Pimentel Matthew A MA Tangkanangnukul Veera V Arevalo Jesusa M G JM Morizono Kouki K Karanikolas Breanne D W BD Wu Lily L Sood Anil K AK Cole Steven W SW
Cancer research 20100907 18
Metastasis to distant tissues is the chief driver of breast cancer-related mortality, but little is known about the systemic physiologic dynamics that regulate this process. To investigate the role of neuroendocrine activation in cancer progression, we used in vivo bioluminescence imaging to track the development of metastasis in an orthotopic mouse model of breast cancer. Stress-induced neuroendocrine activation had a negligible effect on growth of the primary tumor but induced a 30-fold increa ...[more]