Ontology highlight
ABSTRACT:
SUBMITTER: O'Gorman WE
PROVIDER: S-EPMC2940993 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
O'Gorman William E WE Sampath Padma P Simonds Erin F EF Sikorski Rachel R O'Malley Mark M Krutzik Peter O PO Chen Hannah H Panchanathan Vijay V Chaudhri Geeta G Karupiah Gunasegaran G Lewis David B DB Thorne Steve H SH Nolan Garry P GP
Cell host & microbe 20100801 2
Vaccinia immunization was pivotal to successful smallpox eradication. However, the early immune responses that distinguish poxvirus immunization from pathogenic infection remain unknown. To address this, we developed a strategy to map the activation of key signaling networks in vivo and applied this approach to define and compare the earliest signaling events elicited by immunizing (vaccinia) and lethal (ectromelia) poxvirus infections in mice. Vaccinia induced rapid TLR2-dependent responses, le ...[more]